Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Carole Cook Guest Star Donovan Leitch Jr. Guest Star Nancy Linari Guest Star Robin Pearson Rose Guest Star Cathy Lind Hayes Guest Star Jill Holden Guest Star Christopher Boyer Guest Star John O'Brien Guest Star Ricardo Molina Guest Star Rigo Sanchez Guest Star Natalie N. Okamoto Guest Star Kate Anthony Guest Star Yutaka Takeuchi Guest Star Tyshawn Bryant Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Tony Phelan Writer Joan Rater Writer Adam Davidson Director