Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Chris O'Donnell Guest Star Sara Ramirez Guest Star Jeffrey Dean Morgan Guest Star Albert Hall Guest Star Jayne Brook Guest Star Jean Louisa Kelly Guest Star Andrew Borba Guest Star Kathleen M. Darcy Guest Star Noelle McCutchen Guest Star Bryce Robinson Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Elizabeth Klaviter Writer Jeff Melman Director