Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Justina Machado Guest Star Faith Prince Guest Star Arye Gross Guest Star Chris Conner Guest Star Margo Harshman Guest Star Todd Babcock Guest Star Moe Irvin Guest Star Kate Anthony Guest Star Karl T. Wright Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Zoanne Clack Writer Tony Phelan Writer Joan Rater Writer Jeff Melman Director