Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Elizabeth Reaser Guest Star Roger Rees Guest Star Dee Wallace Guest Star Brent Jennings Guest Star Suzanne Cryer Guest Star Tim Hopper Guest Star Marc Vann Guest Star Steven W. Bailey Guest Star Mare Winningham Guest Star Randy Thompson Guest Star Melissa Fitzgerald Guest Star Kate Anthony Guest Star Zibby Allen Guest Star Nichelle Hines Guest Star Liv Hutchings Guest Star Craig Tsuyumine Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Stacy McKee Writer Christopher Misiano Director