Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Kevin McKidd Owen Hunt Guest Star Melissa George Guest Star Mary McDonnell Guest Star Jeffrey Dean Morgan Guest Star August Schellenberg Guest Star Ed Lauter Guest Star Brandon Scott Guest Star Gloria Garayua Guest Star Mark Saul Guest Star Molly Kidder Guest Star Winston Story Guest Star Joseph Williamson Guest Star Nicole Rubio Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Stacy McKee Writer Eric Stoltz Director