Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Omar Epps Dr. Eric Foreman Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Jesse Spencer Dr. Robert Chase Actor Amy Dudgeon Casey Guest Star Anne Dudek Dr. Amber Volakis Guest Star Olivia Wilde Thirteen, Dr. Remy Hadley Guest Star Peter Jacobson Dr. Chris Taub Guest Star Kal Penn Dr. Lawrence Kutner Guest Star Andy Comeau Dr. Travis Brennan Guest Star Edi Gathegi Dr. Jeffrey 'Big Love' Cole Guest Star Tom Wilson Lou Guest Star Michael Michele Dr. Samira Terzi Guest Star Holmes Osborne Dr. Curtis Guest Star Joel Bissonnette John Guest Star Chad Willett CIA Agent Smith Guest Star Nick Warnock Reporter Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Juan José Campanella Director Thomas L. Moran Writer Peter Blake Writer