Lucas Till Angus "Mac" MacGyver Actor George Eads Jack Dalton Actor Justin Hires Wilt Bozer Actor Tristin Mays Riley Davis Actor Meredith Eaton Matty Webber Actor Isabel Lucas Samantha Cage Actor Kamar de los Reyes Captain Delarosa Guest Star Diogo Morgado Carlos Guest Star Marc Menchaca Booth Guest Star Michael Aaron Milligan Pike Guest Star Ana Ayora Kamila Guest Star Ava Davila Adriana Guest Star Rose Bianco Valeria Guest Star Erica Page Lucy Guest Star Todd Jenkins Ash Guest Star Denise Santos Officer Guest Star Isabel De La Cruz Cora Guest Star Xaveria Baird Dean Guest Star Vas Sanchez Jorge Villareal Guest Star Jorge Ferragut Cop Guest Star Van Dron Bad Guy Guest Star Paul Downs Colaizzo Executive Producer Brett Mahoney Executive Producer David Von Ancken Executive Producer Henry Winkler Executive Producer Lee David Zlotoff Executive Producer, Writer Craig S O'Neill Executive Producer Mark Manos Director