Ryan Eggold Dr. Max Goodwin Actor Freema Agyeman Dr. Helen Sharpe Actor Janet Montgomery Dr. Lauren Bloom Actor Jocko Sims Dr. Floyd Reynolds Actor Tyler Labine Dr. Iggy Frome Actor Anupam Kher Dr. Vijay Kapoor Actor John Michael Higgins Jacob Singer Guest Star Marceline Hugot Annie Singer Guest Star Shaleen Mulvany Ansuya Kapoor Guest Star Christine Chang Dr. Agnes Kao Guest Star Kerry Flanagan Marsha Guest Star Alison Luff Alice Healy Guest Star Margot Bingham Evie Garrison Guest Star Megan Byrne Gladys Guest Star Alejandro Hernández ED Nurse Casey Acosta Guest Star Ana Villafañe Dr. Valentina Castro Guest Star Michael A. Henry Dr. Christopher Madden Guest Star Stacie Greenwell Louise Galena Guest Star Jacob Ming-Trent Minister Reid Guest Star Erick Betancourt Security Guard Joe McAdams Guest Star Johnny Wu Craig Lowe Guest Star Jessica Noboa Kelly Lowe Guest Star Matthew Jeffers ED Resident Mark Walsh Guest Star Emma Ramos ED Resident Mariana Guest Star Em Grosland ED Nurse Brunstetter Guest Star Stacey Raymond Paramedic Whitaker Guest Star Kelemete Misipeka Ikaika Namakaokealohahaunaele Guest Star Jimmy Gary Jr. Big Mike Kiggens Guest Star Zach Appelman Sam Singer Guest Star Brandon Ocasio Orderly Perez Guest Star Amber Janea Nurse Guest Star Tim Liu Rodney Guest Star Thomas J. Lillis Jackson Lowe Guest Star Molly Ranson Melissa Singer Guest Star Cristala Carter Larkin Pettah Guest Star David Schulner Executive Producer Peter Horton Executive Producer Kate Dennis Executive Producer Eric Manheimer Executive Producer Seith Mann Director Aaron Ginsburg Writer