Roseanne Barr Roseanne Conner Actor John Goodman Dan Conner Actor Alicia Goranson Becky Conner-Healy Actor Sara Gilbert Darlene Conner Actor Laurie Metcalf Jackie Harris Actor George Clooney Booker Brooks Guest Star Natalie West Crystal Anderson Guest Star Evelina Fernandez Juanita Herrera Guest Star Anne Faulkner Sylvia Foster Guest Star Ron Perkins Pete Wilkins Guest Star Sal Barone "D.J." Conner Guest Star Judy Prescott Miss Crane Guest Star Charlayne Woodard Vonda Green Guest Star Ellen Gittelsohn Director Matt Williams Writer