Melissa Benoist Kara Danvers, Supergirl Actor Chyler Leigh Alex Danvers Actor Mehcad Brooks James Olsen Actor David Harewood Hank Henshaw Actor Jeremy Jordan Winslow "Winn" Schott Actor Chris Wood Mon-El Actor Katie McGrath Lena Luthor Actor Odette Annable Samantha Arias, Reign Actor Amy Jackson Imra Ardeen, Saturn Girl Guest Star Jesse Rath Querl Dox, Brainiac-5 Guest Star Krys Marshall Julia Freeman, Purity Actor Angela Zhou Dr. Grace Parker, Pestilence Actor Greg Berlanti Executive Producer Allison Adler Executive Producer Andrew Kreisberg Executive Producer Sarah Schechter Executive Producer Alexandra La Roche Director Gabriel Llanas Writer Anna Musky-Goldwyn Writer