Dominic West Det. James "Jimmy" McNulty Actor John Doman William A. Rawls Actor Frankie Faison Comm. Ervin H. Burrell Actor Wood Harris Avon Barksdale Actor Domenick Lombardozzi Det. Thomas "Herc" Hauk Actor Deirdre Lovejoy Rhonda Pearlman Actor Wendell Pierce Det. William "Bunk" Moreland Actor Lance Reddick Lt. Cedric Daniels Actor Andre Royo Bubbles Actor Sonja Sohn Det. Shakima "Kima" Greggs Actor J.D. Williams Preston "Bodie" Broadus Actor Seth Gilliam Sgt. Ellis Carver Actor Clarke Peters Det. Lester Freamon Actor Jim True-Frost Det. Roland "Prezbo" Pryzbylewski Actor Michael Kenneth Williams Omar Little Actor Corey Parker Robinson Det. Leander Sydnor Actor Robert Wisdom Howard "Bunny" Colvin Actor Aidan Gillen Thomas "Tommy" Carcetti Actor Jamie Hector Marlo Stanfield Actor Chad L. Coleman Dennis "Cutty" Wise Actor Isiah Whitlock Jr. State Sen. R. Clayton "Clay" Davis Actor Glynn Turman Mayor Clarence V. Royce Actor Reg E. Cathey Norman Wilson Guest Star Amy Ryan Off. Beatrice "Beadie" Russell Guest Star Jermaine Crawford Duquan "Dukie" Weems Guest Star Maestro Harrell Randy Wagstaff Guest Star Julito McCullum Namond Brice Guest Star Mack Wilds Michael Lee Guest Star Gbenga Akinnagbe Chris Partlow Guest Star Robert F. Chew Joseph "Proposition Joe" Stewart Guest Star Anwan Glover Slim Charles Guest Star Melvin Williams Deacon Guest Star Susan Duvall Assistant Principal Marcia Donnelly Guest Star Dravon James Grace Sampson Guest Star Dan DeLuca David Parenti Guest Star Boris McGiver Lt. Charles Marimow Guest Star Gene Terinoni Lt. Jimmy Asher Guest Star Daniel Lee Robertson III Shaun Williams Guest Star Maria Broom Marla Daniels Guest Star Brandy Burre Theresa D'Agostino Guest Star Cleo Reginald Pizana Chief of Staff Coleman Parker Guest Star Frederick Strother State Delegate Odell Watkins Guest Star Ramón Rodríguez Renaldo Guest Star Seith Mann Director Ed Burns Writer Richard Price Writer