Amanda Seyfried Elizabeth Holmes Actor Naveen Andrews Sunny Balwani Actor William H. Macy Richard Fuisz Actor Laurie Metcalf Phyllis Gardner Actor Elizabeth Marvel Noel Holmes Actor Bill Irwin Channing Robertson Actor Utkarsh Ambudkar Rakesh Madhava Actor Stephen Fry Ian Gibbons Actor Michael Gill Chris Holmes Actor Josh Pais Wade Maquelon Actor Michael Ironside Don Lucas Actor Kate Burton Rochelle Gibbons Actor Dylan Minnette Tyler Shultz Actor Alan Ruck Jay Rosan Actor Bashir Salahuddin Brendan Morris Actor Mary Lynn Rajskub Lorraine Fuisz Actor Hart Bochner Larry Ellison Actor James Hiroyuki Liao Edmond Ku Actor Nicky Endres Ana Arriola Actor Camryn Kim Erika Cheung Actor Andrew Leeds Roland Actor Elizabeth Meriwether Executive Producer Elizabeth Hannah Executive Producer Liz Heldens Executive Producer Katherine Pope Executive Producer Rebecca Jarvis Executive Producer Victoria Thompson Executive Producer Michael Klick Executive Producer Michael Showalter Executive Producer Taylor Dunn Executive Producer Jordana Mollick Executive Producer Wei-Ning Yu Writer Francesca Gregorini Director