Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Ryan Phuong Tam Guest Star Brian Stepanek Mr. Givens Guest Star Jason Kravits Dr. Hodges Guest Star Dave Florek Dr. Eberland Guest Star Karly Rothenberg Mrs. Veazey Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Anthony Gioe Writer Nick Mandernach Writer Don Scardino Director