Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Ryan Phuong Tam Guest Star Sarah Baker Ms. Hutchins Guest Star Matt Hobby Pastor Jeff Guest Star Wyatt McClure Billy Sparks Guest Star Billy Gardell Herschel Sparks Guest Star Richard Kind Ira Rosenbloom Guest Star Paul Yen Le Nguyen Guest Star VyVy Nguyen Trang Nguyen Guest Star Phil Morris One Guest Star Anjali Bhimani Zero Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Eric Kaplan Writer Howard Deutch Director