Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Ryan Phuong Tam Guest Star Billy Gardell Herschel Sparks Guest Star Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Sparks Guest Star Ella Allan Bobbi Sparks Guest Star Mia Allan Bobbi Sparks Guest Star Paul Bates Luis Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Tara Hernandez Writer Jeremy Howe Writer Jaffar Mahmood Director