Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Billy Gardell Herschel Sparks Guest Star Sarah Baker Ms. Hutchins Guest Star Matt Hobby Pastor Jeff Guest Star Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Sparks Guest Star Aaron Schwartz Marcus Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Damir Konjicija Writer Dario Konjicija Writer Teagan Wall Writer David Bickel Writer Jaffar Mahmood Director