Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Ryan Phuong Tam Guest Star Valerie Mahaffey Ms. Macelroy Guest Star Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Sparks Guest Star Josh Latzer Hank Guest Star Nick Alvarez Derek Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer David Bickel Writer Eric Kaplan Writer Jeremy Howe Writer Jaffar Mahmood Director