Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Ryan Phuong Tam Guest Star Matt Hobby Pastor Jeff Guest Star Brian Stepanek Mr. Givens Guest Star Rex Linn Principal Petersen Guest Star Melissa Peterman Brenda Sparks Guest Star Isabel May Veronica Guest Star Katherine Von Till Anchor Guest Star Nick Alvarez Derek Guest Star Jordan Leer Bryan Guest Star Travis Guba Pete Guest Star Tiffany Jeneen Shopper 1 Guest Star Jay Brian Winnick Shopper 2 Guest Star Jack Seaver McDonald Jared Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Tara Hernandez Writer Jeremy Howe Writer Connor Kilpatrick Writer Alex Reid Director