Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Sarah Baker Ms. Hutchins Guest Star John Hartman Dr. Goetsch Guest Star Jayne Taini Phyllis Guest Star Duane Shepard Sr. Mr. Bustifer Guest Star Carol Mansell Mrs. Krawcynski Guest Star Dennis Cockrum Mr. Stover Guest Star Carlease Burke Mrs. Ebner Guest Star Chelsea Rae Bernier Lynette Guest Star Karen Constantine Lorraine Guest Star Joe Howard Edwin Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Tara Hernandez Writer Jeremy Howe Writer Steve Holland Writer Maria Ferrari Writer Jaffar Mahmood Director