Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Ryan Phuong Tam Guest Star Isabel May Veronica Guest Star Ed Begley Jr. Dr. Linkletter Guest Star Patricia Belcher Clara Guest Star Kurt Scholler Stan Guest Star Nick Alvarez Derek Guest Star Deb Hiett Susan Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Maria Ferrari Writer Connor Kilpatrick Writer Eric Kaplan Writer Jeremy Howe Writer Mark Cendrowski Director