Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Wallace Shawn Dr. Sturgis Guest Star Craig T. Nelson Dale Guest Star Melissa Peterman Brenda Sparks Guest Star Doc Farrow Coach Wilkins Guest Star Rex Linn Principal Petersen Guest Star Brian Stepanek Mr. Givens Guest Star Valerie Mahaffey Ms. Macelroy Guest Star Emily Berry Janice Guest Star Danielle Pinnock Ms. Ingram Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Connor Kilpatrick Writer Maria Ferrari Writer Tara Hernandez Writer Jeremy Howe Writer Alex Reid Director