Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Wallace Shawn Dr. Sturgis Guest Star Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Sparks Guest Star Taylor Spreitler Sam Guest Star Jaden Martin Jason Guest Star Lauri Hendler Janet Guest Star Bill Chott Dean Guest Star Daniela Leon Clarissa Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Eric Kaplan Writer Tara Hernandez Writer Jeremy Howe Writer Connor Kilpatrick Writer Jaffar Mahmood Director