Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Sparks Guest Star Doc Farrow Coach Wilkins Guest Star Rex Linn Principal Petersen Guest Star Brian Stepanek Mr. Givens Guest Star Ryan Phuong Tam Guest Star Ava Allan Jana Guest Star London Cheshire Marcus Guest Star Michael Croner David Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Connor Kilpatrick Writer Eric Kaplan Writer Tara Hernandez Writer Jeremy Howe Writer Michael Judd Director