Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Melissa Peterman Brenda Sparks Guest Star Doc Farrow Coach Wilkins Guest Star Wyatt McClure Billy Sparks Guest Star Nancy Linehan Charles Peg Guest Star Dan Byrd Pastor Rob Guest Star Mason McCulley Pastor Andy Guest Star Bobo Chang Pastor Charlie Guest Star Andrew Patrick Ralston Pastor Steve Guest Star José Antonio García Nick Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Jeremy Howe Writer Nadiya Chettiar Writer Steve Holland Writer Connor Kilpatrick Writer Marie Cheng Writer Michael Judd Director