Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Ed Begley Jr. Professor Linkletter Guest Star Craig T. Nelson Dale Guest Star Rex Linn Principal Petersen Guest Star Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer Todd Spiewak Executive Producer Jeremy Howe Writer Marie Cheng Writer Ben Slaughter Writer Nick Bakay Writer Yael Glouberman Writer Alex Ayers Writer Kabir Akhtar Director