Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Dan Byrd Pastor Rob Guest Star Emily Osment Mandy Guest Star Melissa Peterman Brenda Guest Star Wyatt McClure Billy Guest Star Rex Linn Principal Petersen Guest Star Nancy Linehan Charles Peg Guest Star Jully Lee Chloe Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Nick Bakay Writer Connor Kilpatrick Writer Steve Holland Writer Jeremy Howe Writer Marie Cheng Writer Alex Reid Director