Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Emily Osment Mandy Actor Wallace Shawn Dr. Sturgis Guest Star Dave Foley Gary Guest Star Doc Farrow Coach Wilkins Guest Star Rex Linn Principal Petersen Guest Star Dan Byrd Pastor Rob Guest Star Brian Stepanek Mr. Givens Guest Star Sarah Baker Ms. Hutchins Guest Star Elijah Collins Stevens Guest Star Andy Umberger Mr. Anderson Guest Star Paul Schackman Mr. Lockhart Guest Star Charles Lott Jr. Jenkins Guest Star Travis Burnett Dean Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Connor Kilpatrick Writer Marie Cheng Writer Steve Holland Writer Nadiya Chettiar Writer Yael Glouberman Writer Nicole Lorre Director