Patrick Wilson Dr. Michael Holt Actor Jennifer Ehle Anna Paul Actor Margo Martindale Rita Perkins-Hall Actor Pablo Schreiber Anton Little Creek Actor Rachelle Lefevre Dr. Kate Sykora Actor Rhys Coiro Dr. Zeke Barnes Guest Star Julie Benz Christina Holt Guest Star Tijuana Ricks Nurse Charisse Guest Star Diane Neal Attorney Kim Fletcher Guest Star Peter Hermann Harrison Curtis Guest Star Desmin Borges Eduardo Sanchez Guest Star Fátima Ptacek Pilar Sanchez Guest Star Robin Weigert Tracy Mathis Guest Star David Wilson Barnes Paul Mathis Guest Star Lee Sheperd Judge Parker Whitford Guest Star J.C. Montgomery ADA Harris Stetham Guest Star Edvin Ortega EMT Guest Star Avery Glymph NYPD Patrol Cop Guest Star Chris Bert Jake Preston Guest Star Jeffrey Hawkins Jake's Father Guest Star Regina Schneider Jake's Mother Guest Star Katie Ross Nurse Maria Guest Star Mackenzie Grey Rebecca Mathis Guest Star Susannah Grant Executive Producer Jonathan Demme Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Neal Baer Executive Producer Daniel Truly Writer Jonathan Greene Writer Ed Ornelas Director