Roman Lutterotti Arthur Voice Bruce Dinsmore David Read, Binky Barnes Voice Daniel Brochu Buster Baxter Voice Ethan Pugiotto D.W. Voice Jodie Resther Francine Alice Frensky Voice Melissa Altro Muffy Voice Arthur Holden Mr. Ratburn Voice Victor Gilbert Carl Voice Max Friedman Cole Brain Voice Sonja Ball Jane Read Voice Holly G. Frankel Fern Walters Voice Ellen David Bitzi Baxter Voice Julie Lemieux Bud, Mrs. Compson Voice Joanna Noyes Grandma Thora Read Voice Jacob Ursomarzo Arthur Voice Dylan Hoerner Carl Voice Eleanor Noble George Voice Tamar Kozlov Prunella Voice Robyn Hickey Catherine Voice Yatharth Bhatt Cheik Voice Andrew Dayton D.W. Voice William Healy Arthur Voice Cameron Ansell Arthur Timothy Read Voice Robert Naylor Dora Winifred "D.W." Read Voice Greg Bailey Director, Producer Marc Brown Writer, Executive Producer Joe Fallon Writer Peter K. Hirsch Writer Dietrich Smith Writer Carol Greenwald Executive Producer