Peter Krause Nick George Actor Donald Sutherland Tripp Darling Actor William Baldwin Patrick Darling Actor Natalie Zea Karen Darling Actor Glenn Fitzgerald Rev. Brian Darling Actor Seth Gabel Jeremy Darling Actor Zoe McLellan Lisa George Actor Blair Underwood Simon Elder Actor Jill Clayburgh Letitia Darling Actor Lucy Liu Nola Lyons Actor Will Shadley Brian Darling Jr. Guest Star Shawn Michael Patrick Clark the Chauffeur Guest Star Candis Cayne Carmelita Guest Star Sheryl Lee Andrea Smithson Guest Star Darcy Rose Byrnes Kiki George Guest Star Laura Margolis Daisy Guest Star John Schneider Congressman Skip Whatley Guest Star Scott Holroyd Chase Alexander Guest Star John Rubinstein Dr. Zwerling Guest Star Roxana Brusso Maria the Maid Guest Star Craig Wright Executive Producer, Writer Greg Berlanti Executive Producer Josh Reims Executive Producer Matthew Gross Executive Producer, Director Bryan Singer Executive Producer Jake Coburn Writer Yahlin Chang Writer Paul Redford Writer Jon Harmon Feldman Writer Robert Berlinger Director Sallie Patrick Writer Bill Chais Writer Emily Whitesell Writer Andrew Bernstein Director Michael Grossman Director Michael W. Watkins Director Dean White Director Michael Schultz Director