Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Dr. Joan Watson Actor Aidan Quinn Capt. Tobias "Toby" Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Mark Moses Oliver Purcell Guest Star Melissa Farman Carly Purcell Guest Star Jake Weber Geoffrey Silver Guest Star Cynthia Darlow Mrs. Dean Guest Star Leigh Ann Larkin Harmony Guest Star Jennifer Regan Agent Claudia Camden Guest Star Shirley Roeca Estella Guest Star Natalie Toro Marisol Guest Star Simon Jutras French Business Man Guest Star Arash Mokhtar Middle Eastern Diplomat 1 Guest Star Al Nazemian Middle Eastern Diplomat 2 Guest Star Sam Freed Oliver's Lawyer Guest Star Robert Doherty Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Michael Cuesta Executive Producer Liz Friedman Writer Christopher Silber Writer John David Coles Director