Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Ophelia Lovibond Kitty Winter Guest Star Andrew Dolan Officer Miles Polano Guest Star Rebecca Brooksher Officer Miles Polano Guest Star Kerry Butler Astrid Guest Star Leslie Silva ATF Agent Hernan Guest Star Shezi Sardar Casey Hatem Guest Star Robert Mammana Niko Buros Guest Star Triney Sandoval George Guest Star Frank Frankson Daren Guest Star Rajesh Bose Officer Doud Guest Star Geoffrey Wigdor Charlie Riggs Guest Star Miriam Silverman Support Group Woman Guest Star Ken Marks Moderator Guest Star Kristine Johnson Reporter Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer Peter Ocko Writer Christine Moore Director