Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Afton Williamson Shauna Scott Guest Star Malcolm Xavier Kai Guest Star Waymon Arnette Enrique Guest Star Susan Misner Loretta Nichols Guest Star Glenn Fleshler Trey McCann Guest Star John Sanders Jeff Harper Guest Star Michael Kostroff Perry Franklin Guest Star Marianne Ferrari Gwen McCann Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer Arika Lisanne Mittman Writer Michael Slovis Director