Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Desmond Harrington Michael Actor John Noble Morland Holmes Guest Star John Horton The Nose Guest Star Tom Hewitt Aldo Ventura Guest Star Roger Bart Kip Lowell Guest Star Pej Vahdat Tim Darsha, Agent Bakshi Guest Star Wrenn Schmidt Cashier, Ellory Guest Star C.J. Wilson Prashant Hobbs Guest Star Phil McGlaston Lowell's VP Guest Star Shawn Andrew ESU Commander Guest Star Jim Noton Sir James Walter Guest Star Twinkle Burke Maggie Foltz Guest Star Jason Manuel Olazabal Nick Evaneer Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer Bob Goodman Writer Guy Ferland Director