Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor James Frain Odin Reichenbach Actor Ophelia Lovibond Kitty Winter Guest Star Tamsin Greig DCI Athelney Jones Guest Star Ravi Kapoor Dr. Garret Halsey Guest Star Saffron Burrows Ruby Carville Guest Star Jamie Thomas King Derek Casey Guest Star Dave Shalansky Tony Guest Star Federico Dordei Beppo Guest Star Tara Summers Nurse Guest Star Tom Vickers Moped Man Guest Star Harry Smith Reporter 1 Guest Star Danny Schwarz Chip Guest Star Ian Harkins Reporter 2 Guest Star Maritza Veer Lola Quinn Guest Star Robert Doherty Executive Producer, Writer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer, Writer Christine Moore Director