Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor James Frain Odin Reichenbach Actor Jordan Gelber M.E. Hawes Guest Star Rob Bartlett Captain Dwyer Guest Star Nick Rehberger Colby Guest Star Chris Diamantopoulos Jason Wood Guest Star Samantha Massell Beth Guest Star Emma Kikue Claire Guest Star Andre Blake Security Coordinator Guest Star Stephen Dexter Guest 1 Guest Star Jeff Applegate Todd Harris Guest Star Maddie Jo Landers Corinna Wood Guest Star Phumzile Sitole Assistant Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer Jeffrey Paul King Writer Christine Moore Director