Kelsey Grammer Dr. Frasier Crane Actor, Director, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Jane Adams Dr. Mel Karnofsky Guest Star Dan Butler Bob 'Bulldog' Briscoe Actor Gigi Rice Regan Shaw Guest Star Katie Finneran Poppy Guest Star Robert Loggia Stefano Guest Star Kim Coles Dr. Mary Guest Star Christine Kludjian Tiffany Guest Star Tom McGowan Kenny Daly Guest Star Saul Rubinek Donny Douglas Guest Star Edward Hibbert Gil Chesterton Guest Star Anthony LaPaglia Simon Moon Guest Star Delaina Mitchell Jessica Guest Star Mary Jo Smith Nurse Guest Star Karen Hensel Bethany Guest Star Richard Stretchberry Virgil Hefflewhite Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer, Director Christopher Lloyd Executive Producer Joe Keenan Executive Producer, Writer Rob Hanning Writer Pamela Fryman Director Sheldon Epps Director Robert H. Egan Director Jon Sherman Writer Dan O'Shannon Writer Sam Johnson Writer Mark Reisman Writer Jay Kogen Writer Bob Daily Writer Chris Marcil Writer