Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Jean Smart Lorna Lynley Guest Star Selma Stern Neighbor Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Christopher Lloyd Executive Producer Joe Keenan Executive Producer Sheldon Epps Director Mark Reisman Writer