Blake Lively Serena van der Woodsen Actor Leighton Meester Blair Waldorf Actor Penn Badgley Dan Humphrey Actor Chace Crawford Nate Archibald Actor Taylor Momsen Jenny Humphrey Actor Ed Westwick Chuck Bass Actor Jessica Szohr Vanessa Abrams Actor Kelly Rutherford Lily van der Woodsen Actor Matthew Settle Rufus Humphrey Actor Michelle Trachtenberg Georgina Sparks Guest Star Nan Zhang Kati Farkas Guest Star Nicole Fiscella Isabel Coates Guest Star Cecily Von Ziegesar Self The Airborne Toxic Event Music Performer David O. Russell Self Josh Schwartz Executive Producer Stephanie Savage Executive Producer Leslie Morgenstein Executive Producer Bob Levy Executive Producer Joshua Safran Executive Producer, Writer Patrick R. Norris Director