Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Jenny O'Hara Guest Star Helen Slater Guest Star Michael Hyatt Guest Star Andrew Bilgore Guest Star Kathe E. Mazur Guest Star Richard Jenik Guest Star C.J. Sanders Guest Star Steven W. Bailey Guest Star Robin Pearson Rose Guest Star Alan Fudge Guest Star Troy Curvey Jr. Guest Star Kathleen M. Darcy Guest Star Alex Stamm Guest Star Linda Klein Guest Star Sarah McDermott Guest Star Sean McDermott Guest Star Savannah McDermott Guest Star John Cappon Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Krista Vernoff Writer Peter Horton Director