Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Chris O'Donnell Guest Star Sara Ramirez Guest Star Jeffrey Dean Morgan Guest Star Ken Marino Guest Star Jesse Head Guest Star Sydney Tamiia Poitier Guest Star Michael Arden Guest Star Michael Milhoan Guest Star Brooke Smith Guest Star Steven W. Bailey Guest Star Robin Pearson Rose Guest Star Patti Tippo Guest Star Kathleen M. Darcy Guest Star Jeremy Rabb Guest Star Keith Sellon-Wright Guest Star Carmen Mormino Guest Star David Paluck Guest Star Kate Mines Guest Star Toby Meuli Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Mark Wilding Writer Daniel Minahan Director