Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Chris O'Donnell Guest Star Kate Burton Guest Star Loretta Devine Guest Star Steven W. Bailey Guest Star Jessica Tuck Guest Star Sarah Utterback Guest Star Joanie Fox Guest Star Pepper Sweeney Guest Star Mia Wesley Guest Star Jeremy Rabb Guest Star Haley Ramm Guest Star Kelli King Guest Star Wayne Lopez Guest Star Frank Merino Guest Star Damon Standifer Guest Star Elizabeth Goldstein Guest Star Matt Crabtree Guest Star Alexandra Brandl Guest Star Paulina Olszynski Guest Star Nicolette Collier Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Daniel Minahan Director