Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Embeth Davidtz Guest Star Eric Dane Dr. Mark Sloan Actor Jillian Bach Guest Star Edwin Hodge Guest Star Liza Lapira Guest Star Francesca Roberts Guest Star Patricia Bethune Guest Star Moe Irvin Guest Star Jeremy Rabb Guest Star Yvette Cruise Guest Star Martin Yu Guest Star Paula Weston Solano Guest Star Jack Axelrod Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Stacy McKee Writer Jessica Yu Director