Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Brooke Smith Dr. Erica Hahn Actor Kate Walsh Guest Star Amy Madigan Guest Star Elizabeth Reaser Guest Star Clea Duvall Guest Star Lauren Stamile Guest Star Kathleen Rose Perkins Guest Star Ken Barnett Guest Star Jason O'Mara Guest Star Gloria Garayua Guest Star Tymberlee Hill Guest Star Winston Story Guest Star Joy Osmanski Guest Star Molly Kidder Guest Star Richard Keith Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Stacy McKee Writer Mark Tinker Director