Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Omar Epps Dr. Eric Foreman Actor Jesse Spencer Dr. Robert Chase Actor Elizabeth Mitchell Sister Mary Augustine Guest Star Lucinda Jenney Sister Mary Eucharist Guest Star Lori Rom Sister Mary Pius Guest Star Ann Dowd Mother Superior Guest Star Dakin Matthews Marvin - Santa Claus Guest Star Taji Coleman Tech Guest Star James Symington Priest Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Greg Yaitanes Director Sara B. Cooper Writer