Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Andrew Creer Detective Bowman Guest Star Rex Linn Nathan Riggs Guest Star Alisha Wainwright Jess Guest Star Graham Miller Gary Guest Star Alex Miller Larry, Steve Guest Star Peter Banifaz Cab Driver Fred Guest Star Audrey Wasilewski Helen Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer