Damon Wayans Roger Murtaugh Actor Seann William Scott Wesley Cole Actor Kevin Rahm Captain Brooks Avery Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Maggie Lawson Natalie Guest Star Paola Lázaro Gutierrez Guest Star Leonor Varela Sofia Guest Star Mykelti Williamson Tom Barnes Guest Star Hemky Madera Benny Avila Guest Star Da'Vinchi Dylan Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer