Michael Sheen William Masters Actor, Producer Lizzy Caplan Virginia Johnson Actor Caitlin FitzGerald Libby Masters Actor Teddy Sears Dr. Austin Langham Actor Annaleigh Ashford Betty DiMello Actor Adam Arkin Guest Star Kevin Christy Guest Star Jocko Sims Guest Star Mather Zickel Guest Star Artemis Pebdani Guest Star Jack Laufer Guest Star Marc Evan Jackson Guest Star Scott Michael Campbell Guest Star Andy Milder Guest Star Lance Barber Guest Star Michelle Ashford Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Judith Verno Executive Producer Amy Lippman Executive Producer, Writer Adam Bernstein Director