Michael Sheen William Masters Actor, Producer Lizzy Caplan Virginia Johnson Actor Caitlin FitzGerald Libby Masters Actor Teddy Sears Dr. Austin Langham Actor Annaleigh Ashford Betty DiMello Actor Kevin Christy Guest Star Ben Koldyke Guest Star Emily Kinney Guest Star Laura Silverman Guest Star Jaeden Martell Guest Star Colin Woodell Guest Star Sarah Silverman Guest Star Josh Charles Guest Star Jerry O'Donnell Guest Star Blake Morgan Ferris Guest Star Michelle Ashford Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Judith Verno Executive Producer Amy Lippman Executive Producer Dan Attias Director Jonathan Igla Writer