Liz Brixius Creator Linda Wallem Creator Evan Dunsky Creator Edie Falco Jackie Peyton Actor Eve Best Dr. O'Hara Actor Peter Facinelli Dr. Cooper Actor Merritt Wever Zoey Actor Paul Schulze Eddie Actor Anna Deavere Smith Gloria Akalitus Actor Dominic Fumusa Kevin Peyton Actor Ruby Jerins Grace Peyton Actor Mackenzie Aladjem Fiona Peyton Actor Bobby Cannavale Dr. Cruz Actor Stephen Wallem Thor Lundgren Actor Arjun Gupta Sam Actor Michael Buscemi God Guest Star Jake Cannavale Carlie Cruz Guest Star Franklin Ojeda Smith Joe Guest Star Caryn Mandabach Executive Producer Randall Einhorn Director